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Korean Journal of Obstetrics & Gynecology 2001;44(7):1237-1241.
Published online July 1, 2001.
Cyclooxygenase-2 Expression in Ovarian Tumors.
Woo Seok Sohn, Bong Sik Min, Chang Mo Kim, Sung Joo Kim, Jung Bae Kang, Hye Rim Park, Pong Rheem Jang
1Department of Obstetrics and Gynecology, College of Medicine, Hallym University, Korea.
2Department of Pathology, College of Medicine, Hallym University, Korea.
Abstract
OBJECTIVE
A large body of evidence suggests that cyclooxygenase-2 (COX-2) is important in tumorigenesis of gastrointestinal and other cancers. This was the study to determine whether COX-2 was also expressed in benign and malignant ovarian tumors. METHODS: We studied the expression of COX-2 in various ovarian tumors [ Benign epithelial tumors (n=10), borderline epithelial tumors (n=12), malignant epithelial tumor (n=12), nonepithelial tumors(n=10) ] by immunohistochemistry. Results of immunoreactivity was classified semiquantitatively based on the proportion and intensity of tumor cell immunostaining. RESULTS: In the epithelial ovarian tumors, the intensity of immunostaining was stronger in the malignant tumors than the benign and borderline tumors (p<0.001). Especially all serous and mucinous malignant tumors (n=9) showed weak and strong immunoreactivity, with 66.7% strong reactivity. None of the nonepithelial ovarian tumors expressed COX-2 immunoreactivity. CONCLUSION: These preliminary data indicate that COX-2 may have a role in carcinogenesis of epithelial ovarian tumors, especially in the serous and mucinous types. COX-2 maybe a target for future research in the tumorigenesis of the epithelial ovarian malignancies.
Key Words: Cyclooxygenase-2, epithelial ovarian tumors


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