Fetal Nuchal Translucency Measurement for Detection of Chromosomal Abnormalities in the First Trimester of High Risk Pregnancy. |
Ji Young Lee, Kyu Ha Choi, Chan Woo Park, Tae Suk Yun, Choo Jin Park, Pong Rheem Jang, Yang Suh Park |
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Abstract |
OBJECTIVE To determine the value of sonographic nuchal translucency measurement for the detection of chromosomal abnormalities in high risk pregnancies. METHOD: The feasibility of nuchal translucency was tested in a prospective study of 1260 pregnancies at 10- 13 weeks' gestation. RESULTS: The nuchal translucency of 3 mm or greater was identified in 41 fetuses (3.2%), 19 of whom proved subsequently by either amniocentesis or postnatal follow-up have chromosomal abnormalities. The sensitivity of nuchal translucency for chromosomal abnormalities was 82.6% (19 of 23 cases), the positive predictive value of nuchal translucency for chromosomal abnormalities detection was 46.3% (19 of 41 cases). CONCLUSION: The observed sensitivity, false-positive rate and predictive value suggest that sonographic nuchal translucency should be undertaken at 10 to 13 weeks of gestation. |
Key Words:
Nuchal translucency, Chromosomal abnormalities, Ultrasound screening |
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