Korean J Obstet Gynecol Search

CLOSE


Korean Journal of Obstetrics & Gynecology 1997;40(11):2605-2608.
Published online January 1, 2001.
A Case of Hyperandrogenism, Insulin Resistance and Acanthosis Nigricans (HAIR-AN) Syndrome.
K T Kim, C J Park, Y K Kim, P R Jang, Y S Park, H K Kim, D M Kim
1Department of Obstetrics and Gynecology, College of Medicine, Hallym University, Seoul, Korea.
2Department of Internal Medicine, College of Medicine, Hallym University, Seoul, Korea.
Abstract
The HAIR-AN syndrome affects between 2% and 5% of hirsute women and is charactedrized by elevated insulin levels due to insulin resistance, acanthosis nigricans, and hyperandrogenemia. The insulin resistance and compensatory hyperinsulinemia is typically due to a decreased number of insulin receptors, decreased functional activity of the receptor or circulating antiinsulin receptor antibodies. Multiple, independent lines of evidence support that chronic hyperinsulinemia causes ovarian hyperandrogenism. Acanthosis nigricans is considered a marker for insulin resistance in hirsute women. Although the association between hyperinsulinemia and hyperandrogenism remains to be fully explained at the molecular level, chronic hyperinsulinemia appears to be an important cause of hyperandrogenism.
Key Words: Hyperandrogenism, Insulin resistance, Acanthosis nigricans


ABOUT
ARTICLE & TOPICS
Article category

Browse all articles >

Topics

Browse all articles >

BROWSE ARTICLES
POLICY
FOR CONTRIBUTORS
Editorial Office
4th Floor, 36 Gangnam-daero 132-gil, Gangnam-gu, Seoul 06044, Korea
Tel: +82-2-3445-2382    Fax: +82-2-3445-2440    E-mail: journal@ogscience.org                

Copyright © 2020 by Korean Society of Obstetrics and Gynecology. All rights reserved.

Developed in M2community

Close layer
prev next