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Korean Journal of Obstetrics & Gynecology 1997;40(11):2464-2472.
Published online January 1, 2001.
A Study of Immunohistochemical Evaluation of bcl-2 Protein and p53 Protein Expression in Epithelial Ovaria Cancers.
Sang Joon Choi, Young Ho Kim, Gyung Chul Rhu, Sei Jun Han, Chang Hun Song, Hyuk Jung, Sung Chul Lim
1Department of Obstetrics and Gynecology, College of Medicine, Chosun University, Kwangju, Korea.
2Department of Pathology, College of Medicine, Chosun University, Kwangju, Korea.
Abstract
Bcl-2 and p53, two proteins, have implicated in apoptosis and among them p53 is known as adverse prognostic factor in a number of tumors. But it is variable in different tissues whether bcl-2 expression and its role are related in the prognosis. The present study was aimed to find the role of bcl-2 and p53 in prognosis of epithelial ovarian cancer. We examined 32 epithelial ovarian cancer specimens of different histologic types and stages by immunohistochemical staining. Bcl-2 protein expression was found in 11/32 epithelial ovarian cancers and it was related in survival(p=0.0038) and p53 accumulation was found in 17/32 epithelial ovarian cancers but it was not rrelated in survival(p=0.0717). But bcl-2 expression and p53 accumulation were not related to the FIGO stages(p>0.05). The analysis of the postoperative course of 32 patients showed that survival depended on the FIGO stages(p=0.001 2) and the histologic type(p=0.009). However, bcl-2 immunohistochemistry identified a subgroup of patients with p53 and bcl-2 positive carcinomas who had not a statistically better outcome(p=0.082) than patients with p53 positive and bcl-2 negative carcinomas. Thus our observations point to different molecular alterations possibly underlying phenotypic diversity of ovarian carcinomas and provide clues for a better understanding of tumor progression in these neoplasms.
Key Words: Epithelial ovarian cancer, bcl-2, p53


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