Effect of Antioxidant on the Toxicity Induced by Cadmium in Preimplantatio Embryos In Vitro.

Hong, Gi Youn; Lee, Bong Joo; Rhee, Hee Sub; Kim, Heung Gon; Min, Bu Kie; Kim, Kie Suk; Park, Seung Taeck

Original Article

Korean Journal of Obstetrics & Gynecology 1997;40(5):935-940.
Published online January 1, 2001.

Effect of Antioxidant on the Toxicity Induced by Cadmium in Preimplantatio Embryos In Vitro.

Gi Youn Hong, Bong Joo Lee, Hee Sub Rhee, Heung Gon Kim, Bu Kie Min, Kie Suk Kim, Seung Taeck Park

¹Department of Obstetrics and Gynecology, College of Medicine, Wonkwang University, Korea.
²Department of Anatomy, College of Medicine, Wonkwang University, Korea.

Abstract

In order to elucidate the mechanism of oxidative damage of cadimu(Cd) on culturedmouse preimplantation embyors.The embryotoxocity of Cd was examined after cultured mouse preimplantation embryoswere exposed to various concentrations of CdCl2. In addition, the protected effect of antioxidant,catalase against Cd-induced embryotoxicity was investigated.CdCl2 decreased the development of cultured mouse preimplantation embryos in dose andtime-dependent manners, and also oxidative damage was involoved in Cd-induced embryotoxicityin mouse preimplantation embryos by the prevention of catalase on Cd-induced toxicity.

Key Words: Embryotoxicity, Cadmium, Catalase, Preimplantation embryos