Korean J Obstet Gynecol Search

CLOSE


Korean Journal of Obstetrics & Gynecology 2005;48(5):1306-1312.
Published online May 1, 2005.
Association of the CYP17 gene polymorphism with the risk of PCOS in Korean women.
Ji Young Lee, Yun Jeong Cha, Sung Eun Hur, Seong Jae Lee, In Sook Sohn, Soo Nyung Kim, Yeon Ah Sung, Hye Won Chung
1Department of Obstetrics and Gynecology, College of Medicine, Konkuk University, Seoul, Korea. chess1@unitel.co.kr
2Department of Obstetrics and Gynecology, College of Medicine, Ewha Womans University, Seoul, Korea.
3Mirae and Heemang Obstetrics and Gynecology Clinic, Seoul, Korea.
4Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Korea.
Abstract
OBJECTIVE
To investigate whether polymorphism of CYP17 gene is associated with the risk of polycystic ovary syndrome (PCOS) in Korean women. METHODS: The 86 PCOS patients and 75 controls were enrolled. Blood samples were collected from 86 patients diagnosed according to the 2003 revised criteria of the Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Age matched women with regular menstruation from same geographic region were recruited on the control subject. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine all individuals' genotype. RESULTS: In women with A1A1 genotype, there was increased PCOS risk and this difference was statistically significant (OR 2.2 (CI 1-4.7)). CONCLUSION: The results suggest that the CYP17 A1A1 genetic polymorphism might be associated with PCOS risk in Korean women.
Key Words: CYP17, PCOS, Polymorphism


ABOUT
ARTICLE & TOPICS
Article category

Browse all articles >

Topics

Browse all articles >

BROWSE ARTICLES
POLICY
FOR CONTRIBUTORS
Editorial Office
4th Floor, 36 Gangnam-daero 132-gil, Gangnam-gu, Seoul 06044, Korea
Tel: +82-2-3445-2382    Fax: +82-2-3445-2440    E-mail: journal@ogscience.org                

Copyright © 2020 by Korean Society of Obstetrics and Gynecology. All rights reserved.

Developed in M2community

Close layer
prev next