| Analysis of C(-634)G polymorphism in the promotor region of the vascular endothelial growth factor gene in Korean women with endometriosis. |
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Hyang Ah Lee, Gyun Ho Jeon, Jeong Won Choi, Sung Hoon Kim, Hee Dong Chae, Chung Hoon Kim, Byung Moon Kang, Young Min Choi |
1Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea. kimsung@amc.seoul.kr
2Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul National University Hospital, Seoul, Korea. |
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| Abstract |
OBJECTIVE
This study was designed to investigate the association between C(-634)G polymorphism in the promotor region of vascualr endothelial growth factor (VEGF) and endometriosis. METHODS: The genomic DNA was extracted from 100 patients with surgically confirmed endometriosis and 100 control group from July 2003 to June 2004. Following extraction of genomic DNA, genotyping of C(-634)G polymorphism of VEGF gene was performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). RESULTS: There was no significant difference in the frequency of CC genotype between the patients with endometriosis (21%) and the control group (19%). No significant difference in the frequency of allele of -634C was noted between the two groups (43.5% vs 44%), either. CONCLUSION: The C(-634)G polymorphism in the promotor region of VEGF gene is not associated with susceptibility to endometriosis in Korean women. |
| Key Words:
Endometriosis, Polymorphism, VEGF gene |
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