A case of advanced ovarian cancer which was treated with topotecan after taxol-cisplatin treatment failed.

Choi, Hyun Soo; Huh, Chu Yeop; Kim, Seung Bo

Case Report

Korean Journal of Obstetrics & Gynecology 2000;43(5):914-917.
Published online January 1, 2001.

A case of advanced ovarian cancer which was treated with topotecan after taxol-cisplatin treatment failed.

Hyun Soo Choi, Chu Yeop Huh, Seung Bo Kim

Abstract

Ovarian cancer has the highest mortality rate among gynecologic malignancies in developed countries. Most women present with advanced disease and require a combination of surgery and chemotherapy. One patient presented with recurrent ovarian cancer was initially treated with taxol and platinum-based compounds. Although response to these agents occurred, tumor progression was evident by elevated CA 125 levels and CT findings after a period of 4 months. This patient was then treated with topotecan and exhibited a response and stopped therapy. Topotecan exhibited activity in this patient with ovarian cancer resistent to both platinum and paclitaxel. We report a case of advanced ovarian cancer which was treated with topotecan after taxol-cisplatin treatment failed.

Key Words: Topotecan, Taxol-Cisplatin, Advanced ovarian cancer